The Relationship Between Glu298Asp and T786-C Gene Polymorphisms of Endothelial Nitric Oxide Synthase and Coronary Slow-flow Phenomenon

Cihan Öztürk, Metin Budak, Gökay Taylan, Ahmet Kenan Yalta

Keywords: Coronary slow-flow, endothelial nitric oxide synthase, Genetic polymorphism

Aim:

This study aims to determine the association between Glu 298-Asp and T786-C gene polymorphisms of endothelial nitric oxide synthase (eNOS) and coronary slow-flow (CSF) phenomenon.

Method:

148 individuals who underwent coronary angiogram (CAG) based on anginal symptoms, exercise testing, or myocardial perfusion scintigraphy were included in the study. Coronary flow was calculated based on TIMI frame counts (TFCs) on CAG. Venous blood samples were drawn from the patients for gene analysis and other biochemical parameters.

Results:

74 patients with a CSF pattern based on TFCs were included as patients and 74 individuals with normal coronary arteries were included as the control group. In the genotypic polymorphism analysis of the patient and control groups, no significant difference was found among individuals with CC, CT, and TT genotypes in terms of T786-C polymorphism (p:0=941) and among individuals with GG, GT, and TT genotypes (p=0.070) in terms of Glu298Asp polymorphism. Also, there was no statistically significant difference with regard to the distribution of the T786-C (p=0.220) and Glu298Asp (p=0.378) polymorphisms between those with single (only one of LAD, CX, or RCA) and those with multi-vessel (at least two or more of LAD, CX, or RCA) CSF patterns.

Conclusions:

Our study demonstrated a null relationship between T786-C and Glu298Asp polymorphisms of the eNOS gene and CSF phenomenon in the Turkish population.

#29