Comparison of Vitamin B12 High Ratios in Adults With and Without Chronic Disease Who Attend to the Hospital

Nurcan Doğan, Özlem Güç Suvak, Süleyman Görpelioğlu

Keywords: Vitamin B12, Chronic diseases, Diabetes Mellitus

Aim:

There are studies showing an association between vitamin B12 elevation and some chronic diseases and malignancies. In this study, we aimed to compare the rates of vitamin B12 elevation in adults with and without chronic disease.

Method:

In this descriptive, retrospective and single-center study, it was evaluated the outpatients who applied to the Family Medicine Outpatient Clinics between 01.06.2021 and 01.06.2022 at Health Sciences University (HSU) Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital. Cases aged 35 years and older with vitamin B12 elevation, with or without chronic diseases in the ICD codes specified in the system, and whose recent blood parameters were checked, were analyzed. Demographic characteristics of the patients (age, gender), vitamin B12 value results, information on whether there is a chronic disease, complete blood parameters, urea, creatinine, ALT, AST values were recorded. IBM SPSS (Statistical Package for Social Sciences) for Windows 25.0 program was used in data analysis.

Results:

Of the 128 cases included in the study, 85 (66.4%) were female and the mean age of the patients was 56.5 (±13.6) years. It was included in the study 68 (53.1%) participants with any chronic disease and 60 (46.9%) without any chronic disease. In our study, vitamin B12 elevation was found to be more significant in patients with dDiabetes Mellitus (DM), one of the chronic diseases.According to its own internal categorization of high vitamin B12, vitamin B12 levels were observed to be significantly very high in individuals with DM, and according to logistic regression, the risk of detecting DM was found to be 0.67 in those with vitamin B12 elevation.

Conclusions:

A significant association was detected between vitamin B12 elevation in individuals with DM. However, there is a need for larger studies due to the limitations of our small number of cases and single-center.

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